Persistent infection of rats with haemorrhagic fever with renal syndrome virus and their antibody responses.

نویسندگان

  • O Tanishita
  • Y Takahashi
  • Y Okuno
  • M Tamura
  • H Asada
  • J R Dantas
  • T Yamanouchi
  • K Domae
  • T Kurata
  • K Yamanishi
چکیده

Newborn (within 24 h after birth), 1-week-old and 6-week-old (adult) rats were inoculated with a Hantaan-related virus (B-1) and attempts were made to isolate the virus from various organs. Virus-specific antigens were detected in various organs of newborn rats. Moreover virus could be isolated from almost all their organs even 25 weeks after infection. In contrast, in rats infected at 6 weeks of age the virus could be isolated from various organs but its concentration decreased progressively with time. The levels of haemagglutination-inhibiting (HI) and neutralizing antibodies to B-1 virus in the sera were measured. In adult rats, HI antibodies were first detected 2 weeks after infection and their titre rose to a maximum after 5 weeks. On the other hand, in newborn rats the levels of antibodies remained low until 5 or 6 weeks after infection and started to increase to a high level more than 9 weeks after infection. Furthermore, in rats infected soon after birth IgM antibodies predominated for a long time and these antibodies also neutralized infectivity at a high level. These data suggest that the induction of a high titre of neutralizing antibodies mainly of the IgM type does not result in virus clearance in newborn rats and that cellular immunity may be important for virus clearance in vivo.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

T Cells and Pathogenesis of Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome

We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical observations and in vitro experiments. In HCPS, hantavirus-specific T cell resp...

متن کامل

Crimean-Congo haemorrhagic fever presenting as thrombotic microangiopathy and acute renal failure.

Crimean–Congo haemorrhagic fever (CCHF), also known as Asian Ebola, is a fatal viral disease that is rapidly increasing worldwide [1,2]. CCHF is a tickborne viral infection characterized by liver dysfunction, ecchymosis, extensive bleeding with shock and disseminated intravascular coagulation [3–5]. The causative agent of CCHF is the virus of genus Nairovirus and family Bunyaviridae [3–6]. The ...

متن کامل

Haemorrhagic fever with renal syndrome: Hantaan virus infection.

Haemorrhagic fever with renal syndrome is a syndrome seen in diseases of varying severity which occur from the Far East across to Western Europe. The most common diseases in the Far East are Korean haemorrhagic fever and epidemic haemorrhagic fever, which are characterised by fever, muscular pains, haemorrhagic manifestations, and proteinuria; the complications of shock and renal failure may le...

متن کامل

Seroprevalance of leptospirosis in patients with fever visited Vaysian Health Center ,Khoramabad, summer 1385

Talei GR1, Sheikhian A2,Mousavi Z3 1. Assistant professor, Department of Microbiology, Faculty of medicine, Lorestan University medical sciences 2. Assistant professor, Department of Immunology, Faculty of medicine, Lorestan University medical sciences 3. B.Sc of laboratory sciences, Lorestan University medical sciences Abstract Background: Leptospirosis is known to be an emerging ...

متن کامل

Assessment of protection against SARS-CoV-2 infection by measuring antibody titer, yes or no!

Dear Editor The current epidemic of the novel Coronavirus disease 2019 (COVID-19) risen from Wuhan, China, turned into a worldwide concern because of its incubation period (2-14 days) and its high transmission rate. The first cases of the infection were reported in December 2019 in Wuhan with symptoms like pneumonia for an unknown reason. Very soon it was known as a novel kind of Coronavirus o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of general virology

دوره 67 ( Pt 12)  شماره 

صفحات  -

تاریخ انتشار 1986